Defects in central DA neurons affect a wide range of neurological disorders including Parkinson's disease ( PD), Schizophrenia and Tourette's disease. 中枢DA能神经元的缺陷将会引起广泛的神经精神障碍,如帕金森氏病(parkinson'SDisease,PD),精神分裂症和tourette's病等,而且许多药物(如可卡因)成瘾也直接和DA能神经传递有关。